Ongoing research Programs

Merger of electrochemical functionalization and solid supported catalysis: The merger of solid-supported metal nanoparticles catalyzed chemical transformations and electrochemical promoted organic synthesis can offer environmentally friendly and sustainable chemical transformations. These catalysts provide recovery and recycling of precious metal based catalysts, minimize the cost of a synthetic method and permit easy separation of catalysts and products. Electrochemical transition metals catalyzed chemical transformation provide a safer and cheaper chemical process avoiding the use of stoichiometric amounts of toxic, polluting, unnecessary chemical oxidants under environmentally friendly and sustainable conditions. Therefore, it would be highly fascinating to merge solid-supported catalysis and electrochemical synthesis., it would enable the full expansion of the scope of organic electrochemistry to new and unexplored dimensions.

Solid supported catalysis: Our group mainly focus on the metal nanoparticles supported on solid support catalyzed cross-coupling reactions.

Medicinal chemistry of hydroxytriazenes: This program centers on the medicinal applications of hydroxytriazenes ligands. The medicinal applications include 1) antidiabetic activity by α-glucosidase and α-amylase enzymes inhibition method 2) antioxidant activity by DPPH and ABTS radical scavenging methods 3) anti-inflammatory activity by carrageen induced paw edema in rates etc. Ultimately, we hope to develop multi-targeted potential molecules to treat diabetes, oxidative damages, and inflammation.

Research Project (Ongoing)

1. Merging of solid-supported catalysis and electrochemistry to develop sustainable C−C cross-coupling reactions | February 2023-ongoing | Amount: 45,81,000 Rs | Grant: EEQ, Science and Engineering Research Board (Delhi, IN) 

Research Project (Completed)

1. Studies on catalytic applications of solid-supported catalysts of palladium and nickel over marble slurry for the C-C coupling reactions | November 2018 to November 2021 |Amount: 17,80,000 | Grant: TARE, Science and Engineering Research Board (Delhi, IN) 

Collaborations

1. Prof. Debabrata Maiti, Department of Chemistry, IIT Bombay, India

2. Prof. I. P. Tripathi, Department of Environmental Sciences, Mahatma Gandhi Gramoday Chitrakoot Vishwvidhyalay, Chitrakoot, Satna, India 

3. Dr. Vanangamudi Murugesan, Department of Medicinal and Pharmaceutical Chemistry, Sree Vidyanikethan College of Pharmacy, Tirupathi, India

Ph.D. Scholars (Alumni)

1. Dr. Varsha Dayma

2. Dr. Jaishri Chopra

Ph. D. Scholars (Working)

1. Krishna Kher

2. Ankita Regar

3. Rashmi Verma (Project Associate)

Publications

(27) Krishna Kher, Mukesh Dhaker, Prabhat Kumar Baroliya, Recent advances in electrochemical functionalization using diazonium salts, Organic Biomolecular Chemistry, 2023, 21, 7052-7061, https://doi.org/10.1039/D3OB00978E.

(26) Trisha Bhattacharya, Prabhat Kumar Baroliya, Shaeel A. Al-Thabaiti, and Debabrata Maiti, Simplifying the Synthesis of Nonproteinogenic Amino Acids via Palladium-Catalyzed δ-Methyl C–H Olefination of Aliphatic Amines and Amino Acids, JACS Au 2023, DOI: 10.1021/jacsau.3c00215

(25) P. K. Baroliya, M. Dhaker, S. Panja, S.A.  Al-Thabaiti, S. M. Albukhari, A. Dutta, D. Maiti, Transition Metal-Catalyzed C−H Functionalization Through Electrocatalysis, ChemSusChem 2023, 16, e202202201.

(24) Kiran Meena, Prabhat K Baroliya; Synthesis, Characterization, Antimicrobial and Antimalarial Activities of Azines Based Schiff Bases and their Pd(II) Complexes, Chemistry and Biodiversity 2023,  e202300158, https://doi.org/10.1002/cbdv.202300158

(23) Laxmi K. Chauhan, Jaishri Chopra, M. Vanangamudi, I. P. Tripathi, Amit Bhargava, A.K. Goswami, Prabhat K. Baroliya; Hydroxytriazenes incorporating sulphonamide derivatives: evaluation of antidiabetic, antioxidant, anti-inflammatory activities, and computational study. Molecular Diversity 2023, 27, 223–237. doi: 10.1007/s11030-022-10420-w.

(22) J. Chopra, V. Dayma, A. Mandal, P. K. Baroliya, D. Maiti, An unprecedented valorisation of marble slurry waste material as solid support for palladium-catalysed Heck and Suzuki reactions, ChemistrySelect 2022, 7, e202200925.

(21) P. K. Baroliya, J. Chopra, T. Pal, S. Maiti, S. A. Al-Thabaiti, M. Mokhtar, D. Maiti; Supported Metal Nanoparticles Assisted Catalysis: A Broad Concept in Functionalization of Ubiquitous C−H Bonds, ChemCatChem 2021, 13, 4655.

(20) Amit Kumar Gupta, Kunal Seth, Kirti Maheshwari, Prabhat Kumar Baroliya, Mukesh Meena, Ashwani Kumar, Vandana Vinayak, Harish; Biosynthesis and extraction of high-value carotenoid from algae. Frontiers in Bioscience (Landmark Edition). 2021, 1;26(6):171-90.

(19) Pallavi Saxena, Vinod Saharan, Prabhat Kumar Baroliya, Vinod Singh Gour, Manoj Kumar Rai, Harish; Mechanism of nanotoxicity in Chlorella vulgaris exposed to zinc and iron oxide. Toxicology Reports 2021, 1;8:724-31.

(18) Kshipra Nimodia, Aruna Solanki, Laxmi Kunwar Chauhan, Ajay Kumar Goswami and Prabhat Kumar Baroliya; Wood-industrial Waste Material as a Potential Sorbent for the Removal of Pb+2 and Co+2 from Mono and Binary Aquatic Metal Solutions, Oriental Journal of Chemistry, 2021, 37(1).

(17) Laxmi Kunwar Chauhan, Kshipra Nimodia, Pradhyuman Singh Ranawat, Ajay Kumar Goswami and Prabhat Kumar Baroliya; Hydroxytriazene Derived from Sulphanilamide: Spectrophotometric and Biological Applications, Oriental Journal of Chemistry. 2020, 36(5).

(16) Varsha Dayma, Jaishri Chopra, Poonam Sharma, Aparna Dwivedi, Indra P. Tripathi, Amit Bhargava, Vanangamudi Murugesan, Ajay K. Goswami, Prabhat K. Baroliya; Synthesis, antidiabetic, antioxidant and anti-inflammatory activities of novel hydroxytriazenes based on sulpha drugs. Heliyon, 2020,  1;6(8):e04787.

(15) Jaishri Chopra, Ajay. K. Goswami, Prabhat K. Baroliya;  An Overview of Solid Supported Palladium and Nickel Catalysts for CC Cross Coupling Reactions. Mini-Reviews in Organic Chemistry. 2020, 1;17(5):589-604.

(14) Poonam Sharma, Varsha Dayma, Aparna Dwivedi, Prabhat K. Baroliya, I.P. Tripathi, Murugesan Vanangamudi, R.S.Chauhan, A.K.Goswami; Synthesis of sulpha drug based hydroxytriazene derivatives: Anti-diabetic, antioxidant, anti-inflammatory activity and their molecular docking studies, Bioorganic Chemistry, 2020 , 1;96:103642.

(13) Shilpa Jain, Varsha Dayma, Poonam Sharma, Amit Bhargava, Prabhat K Baroliya, Ajay K Goswami; Synthesis of some new hydroxytriazenes and their antimicrobial and anti-inflammatory activities. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2020, 19(1), 50-60.

(12) P. K. Baroliya, Ankita Shrimali, Varsha Dayma, Jaishri Chopra; Removal of Cadmium(II) Using Red Powdered Marble Waste from Aqueous Matrix, Indian Journal of Advances in Chemical Science. 2020;8(2):40-3.

(11) Pratibha Sharma, Alpana Soni, Prabhat K. Baroliya, Rekha Dashora & A. K. Goswami; Inhibition of corrosion of Cu (II) in HNO 3 using substituted hydroxytriazene. Protection of Metals and Physical Chemistry of Surfaces. 2016, 52(5):930-5.

(10) Mangilal Regar; P.K. Baroliya; Ashok Patidar; RekhaDashora; Anita Mehta; R.S. Chauhan and A. K. Goswami; Antidyslipidemic and antioxidant effects of novel hydroxytriazenes. Pharmaceutical Chemistry Journal. 2016, 50(5):310-4.

(9) Shilpa Agarwal; P.K. Baroliya; Amit Bhargava; I.P. Tripathi; A.K. Goswami; Synthesis, characterization, theoretical prediction of activities and evaluation of biological activities of some sulfacetamide based hydroxytriazenes. Bioorganic & medicinal chemistry letters. 2016, 15;26(12):2870-3.

(8) Mangilal Regar; P.K. Baroliya; R.S. Chauhan; A.K. Goswami; H-Point Standard Addition Method for Simultaneous Spectrophotometric Determination of Cobalt and Nickel Using 3-Hydroxy-3-phenyl-1-(4-trifluoro-methylphenyl) triazene. Chemical Science. 2016, 5(2):493-9.

(7) Monika Bhalothia; Neha Suman; P.K. Baroliya; Rekha Dashora; A.K. Goswami; Marble slurry waste as a scavenger material for Cr (III) ions from aqueous medium. Desalination and Water Treatment. 2016, 8;57(37):17377-83.

(6) Monika Bhalothia; Shilpa Agrawal; Alpana Soni; P.K. Baroliya; A. K. Goswami; Application of Marble Slurry a Low Cost Waste Material for the Removal of Co (II) Ions from Synthetic Aqueous Solutions. Chemistry & Biology Interface. 2015,  1;5(6).

(5) Pratibha Sharma; Alpana Soni; P.K. Baroliya; Rekha Dashora; A.K. Goswami; Inhibitive action of 3-Hydroxy-3- (4methylphenyl-1-(4- sulphonato (sodium salt) phenyl triazene on Corrosion of Copper in HCl medium, Research Journal of Chemical Sciences, 2015, 5(2), 59-63.

(4) P.K. Baroliya; Mangilal Regar; R.S. Chauhan; A.K. Goswami;  Synthesis, characterization and antimicrobial activities of hydroxytriazenes and their Co (II) complexes. Afinidad. 2014, 31;71(568).

(3) P.K. Baroliya; Anita Mehta; Rekha Dashora; R. S. Chauhan; A.K. Goswami; Photocatalytic cleavage of hydroxytriazenes: a solid-state synthesis of azo-dyes under sunlight irradiation. Research on Chemical Intermediates. 2012, 38(9):2149-53.

(2) Raveendra Singh; Pooja Joshi; Neelam Pareek; Dipen Upadhyay P. K. Baroliya; Amit Bhandari; R. S. Chauhan; A. K. Goswami. Analytical application of m-chlorophenylazo-bis-acetoxime (m-CPABA) in the spectrophotometric determination of Nickel (II). J. Chem. 2011, 3(2):34-8.

(1) Prabhat K Baroliya, Pooja J, Chauhan RS, Goswami AK. Synthesis, characterization and activity prediction of some new class of hydroxytriazenes. Int. J. Chem. Sci. Tech. 2011, 1(1):1-4.

Dr. Prabhat Kumar Baroliya obtained his BSc degree from MLV Govt College Bhilwara in 2006 and MSc (Chemistry) degree from Mohanlal Sukhadia University (MLSU) Udaipur, India in 2008. He has completed his Ph.D. degree from MLSU in 2014 under the guidance of Professor AK Goswami. Dr. Baroliya joined MLSU as an assistant professor in February 2012. He has worked with Professor Debabrata Maiti, IIT Bombay under the Teachers Associateship for Research Excellence scheme of SERB India. His research interests include medicinal chemistry and heterogeneous catalysis over solid support. He has published 25 research articles in national and international journals.

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